afirma gsc suspicious 50

This occurs in 15-20% of biopsies and often results in the need for surgery to remove the nodule. After some research of my own, I decided to leave it. undefined will no longer be visible to you including posts, replies, and photos. Hello. Afirma BRAF V600E o Afirma BRAF testing may be considered for either GSC or FNA suspicious or malignant results. If all nonsurgical GSC benign cases were truly benign, the chance a suspicious nodule was truly a thyroid cancer was 60% and a benign nodule was benign was 100%. Thanks again, Ok so this is all brand new to me so please bear with me. On this topic from this forum member bmcm2girls said she too had a false suspicious result from the Afirma test and her nodule was benign when removed. This study investigated the outcome of the thyroid nodules deemed to be "suspicious" by the Afirma GEC in a high risk population. He said there was no lymph node involvement but there's no way to tell until final path. Finally, at the endocrinologist's visit, he told me the results came back as suspicious for papillary cancer on both sides, and that I'd need to have a TT. Follow-up of atypia and follicular lesions of undetermined significance in thyroid fine needle aspiration cytology. http://www.glandsurgery.org/article/view/1002/1193 Biotech Strategy Blog in this post by Pieter Droppert June 28,2012 Also mentions 48% of nodules falsely called "suspicious" for cancer and can cause many people to have unnecessary thyroid surgery when they don't have cancerous thyroid cells! Thyroid 29:11151124. I understand that Afirma tends to have a lot of false positives, but it's supposed to be fairly accurate for negative results. For some reason, my long time best friend is one of the least supportive in all of this. I called my husband before I even received the callback, and couldn't stop crying. Wow! Only when I had a follow up visit with a cardiologist in JAn.of 2016 he noticed the results after requesting the previous scan results. Local surgical pathology diagnoses were available for 11 of these nodules. For those of you that had a thyroidectomy, how long did it take for you to realize that the medicine was or was not enough for you? What have been your experinces with AFIRMA? I had the ultrasound, and am waiting for my appointment with her to go over the images. He also says that out of 61 follicular neoplasms that were benign the Afirma test misclassified 31 of them as suspicious. Until now, Afirma has been available as two tests: Afirma GSC and Afirma Xpression Atlas (XA). I posted the below post on this forum on several different topics since 2013. In this discussion of the Afirma test from 2013 on this board several people also had false results from the Afirma test all false suspicious except for the first, reply from member dacooper12 who said that the Afirma test said her nodule was benign but later she had her thyroid removed and found out that it was actually pap cancer that spread into her central lymph node. The Afirma Genomic Sequencing Classifier (GSC) was developed and clinically validated to utilize genomic material obtained during the FNA to accurately identify benign nodules among those deemed cytologically indeterminate so that diagnostic surgery can be avoided. However, I was not informed of this. But, she ordered another ultrasound because she wants to see the images herself, rather than just rely on reports from the radiologist. Careers. I asked her if I have permission to email and post these articles and she said yes,they are for the public. Epub 2020 Mar 17. Thyroid nodule: an abnormal growth of thyroid cells that forms a lump within the thyroid. I am very resistant to the thought of having a gland removed that is functioning perfectly fine, if it isn't cancer. Therefore, a new version of the Afirma test was created called a gene sequencing classifier (GSC) to better predict thyroid cancers in indeterminate nodule while still being able to rule out cancer in benign nodules. Please let me know what you think. New Data Show Strong Performance of Veracyte's Afirma GSC in Real-World Historically, most patients with indeterminate thyroid nodule biopsies were referred for surgery though most would ultimately not have thyroid cancer (around 75% or more would have an unnecessary surgery). While most thyroid nodules are non-cancerous (Benign), ~5-10% are cancerous. Living beings depend on genes, as they code for all proteins and RNA chains that have functions in a cell. Home Patients Portal Clinical Thyroidology for the Public October 2016 Vol 9 Issue 10 p.11-12, CLINICAL THYROIDOLOGY FOR THE PUBLIC I know how frustrating, scary and expensive this whole process is.I am sorry that you are going through it!! Thoughts or experiences?? Here's what a friend of mine wrote who is a retired neurologist: "They can both be right for different reasons, or from different perspectives. This test is performed by the company Veracyte Inc. BACKGROUND Thyroid nodules are very common, occurring in 30-50 % of patients. 42 year old female. Results: Afirma result was suspicious in 69 cases. I'm a 57 year old male who took a full body scan 6 1/2 years ago and among other things a small 1 cm nodule was found on the right lobe of my thyroid. Methods: Thyroid Nodules: https://www.thyroid.org/thyroid-nodules/. At this point, I was exasperated by all of the running around, but fine. Then in December 2014 I thought to have it checked again, with the same results although this time I had it send for the Afirma testing which I was told is more accurate test for cancer. That didn't sit well with me. Unable to load your collection due to an error, Unable to load your delegates due to an error. I'd done enough research to know that Thyroid cancer is generally treatable, and was sure to tell them about that. https://www.inspire.com/groups/thyca-thyroid-cancer-survivors-association/discussion/genetic-test-two-different-results/reply/6888430/?msg_activity=reply_posted. My Endo thinks I should see a thyroid surgeon and my other doctor wants to repeat ultrasounds in 4 months, adopting a wait and see approach. What should I know? These gene patterns are better at ruling out thyroid cancer in an indeterminate nodule than confirming cancer. Repeat Fine Needle Aspiration Cytology Refines the Selection of Thyroid Nodules for Afirma Gene Expression Classifier Testing. My radiologist determined that the smallest one had follicular cancer cells in her description but called it indetermined. And is this what that recent October 2015 WSJ article was hinting at.having people with certain types of cancer of the thyroid not undergo surgery at all but just adopt a wait and see posture? It seems like with every ultrasound, some new suspicious characteristic pops up. The Afirma GSC is a cancer rule-out test with a high negative predictive value so that cytologically indeterminate (Bethesda III/IV)2thyroid nodules with an Afirma GSC benign result can be considered for clinical observation in lieu of diagnostic surgical resection (Fig. An important limitation of this study is that the authors did not examine the rate of noninvasive follicular variant papillary thyroid cancer in specimens that were not reported as suspicious by the GEC test. Glad to have found Inspire to learn more, and support others, and receive support. I am so new to all this that I don't know what this means. However, FVPTC is currently classified as a type of "papillary" carcinoma, so the rate of diagnosis is also going to fall pretty substantially. No parathyroid tissue identified. Molecular testing for indeterminate thyroid nodules: Performance of the Afirma gene expression classifier and ThyroSeq panel. I have made an appointment with another endocrinologist, but just to talk to him. And she said her surgeon said that this test is not very reliable and that meanwhile she has a large bill from the company. Indeterminate means the pathologist cannot tell if the nodule is benign or malignant with certainty. Recommended surgery for suspicious cancer cells. There was no follow up in 13% of cases and 87% were resected (50% lobectomies and 50% total thyroidectomies). The surgeon recommended complete removal of my thyroid. How do Afirma GSC & Xpression Atlas tests work? What do they mean Thus, 54 NIFTP cases were established, all with a suspicious Afirma GEC result. The doc mentioned the thyroid and upon a physical exam felt the nodule, leading to the rest of the testing. The overall PPV of an Afirma GSC suspicious nodule was 47%, regardless of variant/fusion status. WHAT ARE THE IMPLICATIONS OF THIS STUDY? Afirma Gene Expression Classifier: a test for a group of molecular markers in thyroid biopsy specimens in order to determine the likelihood that a thyroid nodule is benign or cancerous. So I was reading about the new kind of fna biopsy called Afirma, and I guess that my question is, is it worth getting it as a second opinion or should I go through with the surgery because of the results not being undetermined. -Lymph Node US: Mostly clear in neck, 1 ovoid focus in submandibular region that may be enlarged LN or Submandibular Lesion Each of my pre-surgical tests are pointing more and more in the wrong direction. Should I be treating this as a Hurthle Cell Lesion, or should I just relax. Among the 22 with only a TP53 alteration, the first 16 consecutive nodules were included (7 nodules were Bethesda III and 9 nodules were Bethesda IV). http://onlinelibrary.wiley.com/doi/10.1002/cncy.21455/full. However, researchers found that when the Afirma GSC identified a thyroid nodule with a TSHR mutation as suspicious, the risk of malignancy was 15.3%, a level of risk for which most physicians. http://biotechstrategyblog.com/2012/06/veracyte- afirma-gene-expression-classifier-thyroid-cancer- diagnostic-test.html/ I'm sure that over the years as more people have this Afirma test done,there will be even more people posting on thyroid and general health boards about getting false "suspicious" results from it! PMC Am I being reasonable? I opted to have the TT and it turned out it was cancerous and had spread to a few lymph nodes, so then I had right and left central neck dissections as well. Any help really will be appreciated. the nodule was only 1.5 cm and I really had no concerning symptoms. Please, I am looking for any and all thoughts. Now, I will most probably undergo surgery, I requested only the right side be removed and they will have a pathologist look at it while I am under and then decide if they remove the whole thing. Frontiers | Thyroseq v3, Afirma GSC, and microRNA Panels Versus Performance of Afirma Gene Sequencing Classifier versus - ScienceDirect A. Method: Once you go down the hole, there are no good statistics to guide you in making rational decisions in an irrational area of medicine - AND as you know, no decisions in medicine in even cut and dried cases are so simple as to have no opposing point of view. Also difficult is the reaction from others. Patients usually return home or to work after the biopsy without any ill effects. Found an endocrinologist who is willing to work with me on some more testing. I had my surgery in NYC, it took 2 hours, and I went home the same day. One of the hardest things about all of this is the adjustment. Fingers crossed they come back negative for cancer! Mine did, and that can also be a sign of cancer. I'm not sure what the exact terminology is going to be. Patients usually return home or to work after the biopsy without any ill effects. The doctor uses a very thin needle to withdraw cells from the thyroid nodule. Afirma said NEGATIVE for BRAF and Meduliary but still assigned a classification of "Suspicious" with 40% chance of cancer. He recently emailed me back and said,as we discusssed on the phone,he agrees with many of my concerns about the Afirma test. 2017;45:308-311. In May 2013 I spoke to Barbara Rath Smith the executive director of The American Thyroid Association and she said she was going to email articles as files to download and she did. The Afirma gene sequencing classifier (GSC) performs better in Example of an Afirma patient report of a hypothetical 1.5 cm thyroid

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